报告人：严军　博士生导师，研究员

报告人介绍：

1998-2003   美国纽约大学物理系   博士
2003-2006   美国阿拉斯加大学   博士后

2006-2015  中科院－德国马普学会计算生物学研究所 研究员
2015-至今     中科院上海生科院神经科学研究所   研究员

主要研究工作内容：

1.全脑介观脑图谱、神经元全脑投射图谱的重建与分析；

 2.采用计算生物学、生物信息学、系统生物学的方法，针对小鼠、斑马鱼等模式生物开展生物节律神经网络、基因调控网络的研究。

代表性论文(*通讯作者)：  

1.Fan, Z., Zhao,  M., Joshi, P., Li, P., Zhang, Y., Guo, W., Xu, Y., Wang, H., Zhao, Z., Yan, J.  (2017) A class of circadian long non-coding RNAs mark enhancers modulating  long-range circadian gene regulation. Nucleic. Acids. Res. doi:  10.1093/nar/gkx156

2.Xu, Y., Guo, W.,  Li, P., Zhang, Y., Zhao, M., Fan, Z., Zhao, Z., Yan, J. (2016) Long-range  chromosome interactions mediated by cohesin shape circadian gene expression.  PLOS Genetics 10.1371

3.Li, Y., Li, G.,  Görling, B., Luy, B., Du, J., and Yan, J. (2015) Integrative Analysis of  Circadian Transcriptome and Metabolic Network Reveals the Role of de novo Purine  Synthesis in Circadian Control of Cell Cycle. PLoS computational biology. 11(2):  e1004086.

4.Liu, J., Wang,  X., Li, J., Wang, H., Wei, G., Yan, J. (2014) Reconstruction of the Gene  Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role  in Early Development of the Mouse Brain. PLoS computational biology.  10(10):e1003884.

5.Liu, Y., Hu, W.,  Murakawa, Y., Yin, J., Wang, G., Landthaler, M., and Yan, J. (2013).  Cold-induced RNA-binding proteins regulate circadian gene expression by  controlling alternative polyadenylation. Scientific reports 3, 2054.

6.Li, Y., Li, G.,  Wang, H., Du, J., and Yan, J. (2013). Analysis of a gene regulatory cascade  mediating circadian rhythm in zebrafish.PLoS computational biology 9,  e1002940.

7.Wang, H., Liu,  Y., Briesemann, M., and Yan, J. (2010).Computational Analysis of Gene  Regulations in Animal Sleep Deprivation.Physiol Genomics 42,  427-436.

8.Shao, C., Liu,  Y., Ruan, H., Li, Y., Wang, H., Kohl, F., Goropashnaya, A.V., Fedorov, V.B.,  Zeng, R., Barnes, B.M., Yan, J. (2010).Shotgun proteomics analysis of  hibernating arctic ground squirrels.Mol Cell Proteomics 9, 313-326.

9.Yan, J., Wang,  H., Liu, Y., and Shao, C. (2008). Analysis of gene regulatory networks in the  mammalian circadian rhythm.PLoS computational biology 4, e1000193..

报告二题目：感知与抉择的神经环路运算

报告人：徐宁龙　博士生导师，研究员

报告人介绍：

1999-2006   中国科学院神经科学研究所   博士
2006-2008   美国冷泉港实验室   博士后

2008-2013   美国 HHMI Janelia Research Campus 博士后

2013-至今     中科院上海生科院神经科学研究所   研究员

主要研究方向：

  1.  我们在执行听觉感知抉择任务的小鼠中，使用双光子显微镜观察大脑皮及皮层下神经元的电信号，以揭示听觉感知与行为抉择的神经编码原理；

2.  我们使用光遗传学和化学遗传学等神经环路干预技术，揭示各个脑区及它们之间形成的环路在感知与抉择中的作用机制；

3.  我们与人工智能研究人员合作，探索如何将动物面对复杂感觉信息进行行为抉择的神经计算原理应用于机器智能技术开发。

代表成果

1. Wang Z, Xu NL, Wu CP, Duan S*, and  Poo MM*, Bidirectional changes in spatial dendritic integration accompanying  long-term synaptic modifications. Neuron, 37: 463-72  (2003).

2. Xu NL, Ye CQ, Zhang XH*, and Poo  MM*, Coincidence detection of synaptic inputs is facilitated at the distal  dendrites after long-term potentiation induction. J. Neurosci., 26: 3002-3009  (2006).

3. Xu NL, Harnett MT,  O’Connor DH, Huber D, Williams SR, Svoboda K., Magee JC*,  Nonlinear dendritic integration of sensory and motor input during an active  sensing task. Nature, 492: 247-251 (2012).

4. Petreanu L, Gutnisky DA, Huber D,  Xu NL, O’Connor DH, Tian L, Looger L, and Svoboda K*,  Activity in motor-sensory projections reveals distributed coding in  somatosensation. Nature, 489: 299–303  (2012).

5. Harnett MT, Xu NL, Magee JC*,  Williams SR*, Potassium Channels Control the Interaction between Active  Dendritic Integration Compartments in Layer 5 Cortical Pyramidal Neurons.  Neuron, 79: 516-529 (2013).

6. Chen JL*, Andermann ML, Keck T, Xu  NL, and Ziv Y, Imaging Neuronal Populations in Behaving Rodents: Paradigms for  Studying Neural Circuits Underlying Behavior in the Mammalian Cortex. J.  Neurosci., 33(45): 17631-17640 (2013).

7. Guo ZV, Hires SA, Li N, O'Connor  DH, Komiyama T, Ophir E, Huber D, Bonardi C, Morandell K, Gutnisky D, Peron S,  Xu NL, Cox J, Svoboda K*, Procedures for Behavioral Experiments in Head-Fixed  Mice. PLoS ONE , 9, e88678 (2014).

时间：2018年4月25日下午6：00

地点：主楼107欢迎广大师生参加！